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Patient Friendly Pain Reliever
NuZiB
Celecoxib
100mg & 200mg Capsules

* Effectively reliefs pain & inflammation in OA & RA.
* Effectively superior in the managment of Acute pain
* Outstanding GI tolerance & safety profile.
* Convenient dosage.

New Celecoxib inhibits COX-2 for relief of pain and inflammation in both osteoarthritis and rheumatoid arthritis,but maintains GI teact integrity because it does not inhabit COX-1

ARACHIDONIC ACID
Traditional

COX-1	NSAID's	COX-2
cox-1 is a house keeping enzyme.it primarily mediates the production of prostaglandins that protect and regulate normal cell function in all cells,including the GI teact and platelets.		cox-2 is triggered by immune or inflammatory stimuli. it primarily produces prostaglandins that mediate inflammation and pain.

Prostaglandins		Prostaglandins
Inhibition Undesirable		Inhibition desirable
Primarily Homeostasis Platelets Aggregation GI Cytoprotection		Primarily Sites Of inflammation and Pain.

Unlike Conventional NSAIDs.

NUZIB (Celecoxib)

selectiverly inhibits COX-2

Superior Safity Profile
Reducing the risk of recurrent Ulcer Bleeing in patients with Arthritis.

Products	No.of Patients	Dose for Six months	Recurrent Ulcer Bleeding
Celecoxib & Placebo	144	200mg BID + Placebo	7
Diclofenac & Omparazole	143	75mg Diclofenac BID & 20mg Omeprazole	9

Safety Profile
Ia a CLass(Celecoxib Long-term Arthritis Safety Study) study was a randomized controlled trial
designed to compare celecoxib(400mg twice daily) with other NSAID"s Diclofenac(75mg twice daily)
and ibuprofen (800mg 3 times a day)

NUZiB (Celecoxib) Provides outstanding safety profile.

NUZiB (Celecoxib) Provides powerful
pain relief in OA & RA as compared to
conventional NSAIDs.

Unlike conventional NSAIDs.
NUZiB (Celecoxib)
selectiverly inhibits COX-2

WITH GREATER ECONOMY
Strength	NUZIB	Brand 1	Patient's Saving
Cap. 100mg	Rs.4.40	Rs. 6.00	Rs. 1.60 per Cap.
Cap. 200mg	Rs7.80	Rs.10.00	Rs. 2.20 per Cap.