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Untitled Document

Variba
(Ribavirin)

Oral Treatment With Interferon Combination In H.C.V

As Viral infection is most common cause of Chronic Hepatitis C.

Ribavirin has......broad spectrum activity against R.N.A & D.N.A viruses.

1.Sheila Sherlock& James Dooly,"Diseases if the Liver & Biliary System."

Combination of Ribavirin and interferon world wide documented as first line treatment of Chronic Hepatitis C

"Subsequent studies showed that combination of interfreon alpha 2b plus Ribavirin is more
effective in achieving a sustained response than interferon alpha 2b alone in the treatment of
patients with chronic Hepatitis C."

Conclusion

The virologicand histologic sustained response rate were 31% to 43% with RIbavirin and interferon
combination compared to 6% to 19 % with interferon alone.

These results Led to:
F.D.A. approval in December 1998 for combination therapy of Ribavirin and interferon in
patient with chronic H.C.V

F.D.A. showed further confidence on Ribavirin as....

August 8,2001 F.D.A. approved newer Interferon (PEGINTERFERON alpha 2b) in combination with Ribavirin for
the treatment of chronic Hepatitis C.

.Preferred 1st choice treatment in combination with interferon alpha.
.provde higher and sustained virologic & histologic response.
Price Comparison (Oral)

(Ribavirin)	Cost	Daily Cost	Duration of Treatment in weeks	Cost of Treatment
Variba	400mg cap	400mg 1 TDS	Duration of Treatment in weeks	Rs.15,120
Variba	30	90	24	Rs.15,120
Brand	Not Available In Pakistan
!st Generic	Rs.65.00	Rs.195.00	24	Rs. 32,760

Variba Capsules Presentations

100mg:Box containing 1 x 10's in blister
200mg: Boz containing 1 x 10's in blister
400mg :Box containing 1 x 10's in blister

Variba is economical by
Rs. 17,640/-(24 weeks)

Variba is economical by
Rs.35,280/- (48 weeks)